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Furthermore, MC4R-deficient mice develop severe obesity accompanied by markedly elevated plasma leptin concentrations and leptin resistance, failing to respond to leptins anorectic and cardiovascular effects [58, 59]

Acknowledgements This work was supported by the National Key R&D Program of China (2021YFB3801000), Regional Key Project of National Natural Science Foundation of China (U20A20385), National Natural Science Foundation of China (22222503), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB36000000) and Overseas High-end Talents Introduction Program (G2022011023L)

However, both in health and disease states, non-coding RNAs play a major part in the regulation of epigenome, particularly targeting the associated enzymes at the posttranscriptional level (Iorio et al., 2010)